Alcohol and Its Biomarkers: Clinical Aspects and Laboratory by Amitava Dasgupta

By Amitava Dasgupta

Alcohol and Its Biomarkers: medical elements and Laboratory Determination is a concise advisor to all presently recognized alcohol biomarkers, their medical software, and the laboratory tools used to realize them. Pathologists can use this source to appreciate the restrictions and value elements linked to every one approach for picking convinced alcohol biomarkers. furthermore, interferences in those determinations are mentioned, in order that clinicians can comprehend the factors of falsely increased biomarkers and pathologists and laboratory scientists can possibly put off them. The ebook specializes in the analytical equipment used to become aware of alcohol in blood and urine, the constraints of alcohol selection utilizing enzymatic equipment, and the diversities among medical and forensic alcohol dimension. Chapters additionally conceal state-of-the-art alcohol biomarkers for power use.

  • Focuses at the analytical tools used for detecting alcohol in blood and urine besides the pitfalls and obstacles of alcohol selection utilizing enzymatic methods
  • Explains the variation among scientific and forensic alcohol measurement
  • Includes a quick evaluation of some great benefits of eating alcohol carefully and the risks of heavy drinking

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2 Alcohol Absorption: Effect of Food................. 3 First-Pass Metabolism of Alcohol ................. 4 Alcohol Metabolism.......... 1 Non-Oxidative Pathways of Alcohol Metabolism.................. 2 Factors Affecting Alcohol Metabolism .... 1 Polymorphism of Alcohol Dehydrogenase Genes ........................... 1 Polymorphisms of Alcohol Dehydrogenase and Aldehyde Dehydrogenase Genes that Protect Against the Development of Alcohol Use Disorder ............... 2 Polymorphism of Alcohol Dehydrogenase and Aldehyde Dehydrogenase Genes that may Increase the Risk of Developing Alcohol Use Disorder..

Alcohol Clin Exp Res 2009;33:1025À32. [85] Numi K, Methuen T, Maki T, Lindstedt KA, et al. Ethanol induces apoptosis in human mast cells. Life Sci 2009;85:678À84. [86] Baum MK, Rafie C, Lai C, Sales S, et al. Alcohol use accelerates HIV disease progression. AIDS Res Hum Retrovir 2010;26:511À18. [87] Boe DM, Vandivier RW, Burnham EL, Moss M. Alcohol abuse and pulmonary disease. J Leukocyte Biol 2009;76:1097À104. [88] Emanuele N, Emanuele MA. Alcohol alters critical hormonal balance. Alcohol Health Res World 1997;21:53À64.

This enzyme is a ubiquitously expressed formaldehyde dehydrogenase with a very low affinity for ethanol. The major function of this enzyme is to oxidize formaldehyde to formic acid and to terminate nitric oxide signaling. The class III ADH is the only enzyme detected in the brain and plays a minor role in overall metabolism of ethanol. The class IV ADH is encoded by the ADH7 gene, which produces the sigma (σ) subunit.

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