Abrams' Clinical Drug Therapy: Rationales for Nursing by Sandra Smith, Geralyn Frandsen

By Sandra Smith, Geralyn Frandsen

This well known center nursing pharmacology textbook presents certain insurance of nursing interventions for drug remedy with similar rationales. hugely praised for its geared up and readable presentation, the textual content explains the "why" at the back of each one nursing motion, and emphasizes how medicinal drugs paintings another way in numerous sufferers. The tenth version has a brand new clean layout and procedure with an extra concentrate on sufferer security built-in into the textual content.

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Extra info for Abrams' Clinical Drug Therapy: Rationales for Nursing Practice (10th Edition)

Sample text

When drug molecules chemically bind with cell receptors, pharmacologic effects result from agonism or antagonism. Agonists are drugs that produce effects similar to those produced by naturally occurring hormones, neurotransmitters, and other substances. Agonists may accelerate or slow normal cellular processes, depending on the type of receptor activated. For example, epinephrine-like drugs act on the heart to increase the heart rate, and acetylcholine-like drugs act on the heart to slow the heart rate; both are agonists.

Washington, DC: National Academies Press. The Joint Commission. org 12/10/2012 3:08:15 PM CHAPTER 1 Karch AM. 2011 Lippincott's Nursing Drug Guide. Philadelphia, PA: Lippincott Williams & Wilkins. http://www. com Quality and Safety Education for Nurses (QSEN). , Byrne, F. , & Cohen, M. R. (2010). Shaping systems for better behavioral choices: Lessons learned from a fatal medication error. Joint Commission Journal on Quality and Patient Safety/Joint Commission Resources, 36(4), 152–163. indd 15 Introduction to Pharmacology 15 The Joint Commission.

To act on body cells, drugs given for systemic effects must reach adequate concentrations in the blood and other tissue fluids surrounding the cells. Thus, they must enter the body and be circulated to their sites of action (target cells). After they act on cells, they must be eliminated from the body. How do systemic drugs reach, interact with, and leave body cells? How do people respond to drugs? The answers to these questions are derived from cellular physiology, pathways and mechanisms of drug transport, pharmacokinetics, pharmacodynamics, and other basic concepts and processes that form the foundation of rational drug therapy and the content of this chapter.

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